NewslettersDermal Cell NewsCDK12 Is Hyperactivated and a Synthetic-Lethal Target in BRAF-Mutated MelanomaBy Laurisa Dohm - October 31, 20220219Scientists found that melanoma cells harbored constitutively high CDK12 activity, and that its inhibition decreased the expression of long genes containing multiple exons, including many genes involved in DNA repair.[Nature Communications]Full Article