Targeted Activation of GPER Enhances the Efficacy of Venetoclax by Boosting Leukemic Pyroptosis and CD8⁺ T Cell Immune Function in Acute Myeloid Leukemia

The authors demonstrated that pharmacological activation of G protein-coupled estrogen receptor by G-1 combined with Venetoclax resulted in synergistic antileukemic activity in vitro and in vivo.