RAB3D/MDM2/β-Catenin/C-MYC Axis Exacerbates the Malignant Behaviors of Acute Myeloid Leukemia Cells In Vitro and In Vivo

The loss- and gain-of-function experiments demonstrated that RAB3D promoted growth, enhanced colony formation, and accelerated G1/S transition of U937, THP-1 and KG-1 in AML cells .