DOT1L Regulates Ovarian Cancer Stem Cells by Activating β-Catenin Signaling

H3K79 methyltransferase disruptor of telomeric silencing-1-like (DOT1L) was upregulated in ovarian CSCs vs. non-CSCs. shRNA-mediated DOT1L knockdown decreased the aldehyde dehydrogenase + cell population, impaired the tumor initiation capacity of ovarian CSCs, and blocked the expression of stemness-associated genes