Rewiring Glucose Metabolism Improves 5-FU Efficacy in p53-Deficient/KRASG12D Glycolytic Colorectal Tumors

Scientists analyzed the 5-fluorouracil (FU) response in patient-derived organoids that reproduce the different stages of colorectal cancer and found that 5-FU induced pyrimidine imbalance, which led to DNA damage and cell death in the actively proliferating cancer cells deficient in p53.