Hyperglycemia with or without Insulin Resistance Triggers Different Structural Changes in Brain Microcirculation and Perivascular Matrix

Researchers investigated the high fat-high sucrose feeding model and streptozotocin-induced type-1 diabetes mellitus model to study the early effects of hyperglycemia to demonstrate the brain microcirculatory changes, perivascular ECM alterations and 3D-reconstructed cleared brain tissues.