Single Cell Transcriptomics Reveals Distinct Transcriptional Responses to Oxycodone and Buprenorphine by iPSC-Derived Brain Organoids from Patients with Opioid Use Disorder

To understand how opioids modulated brain cell type function at the single-cell level, researchers performed single nucleus RNA-seq using iPSC-derived forebrain organoids from three male opioid use disorder subjects in response to oxycodone, buprenorphine, or vehicle for seven days.