iPSCs Derived from Esophageal Atresia Patients Reveal SOX2 Dysregulation at the Anterior Foregut Stage

To mimic the early development of the esophagus and trachea, investigators differentiated iPSCs from esophageal atresia/tracheoesophageal fistula patients, and iPSCs and ESCs from healthy individuals into mature 3D esophageal organoids.