A Grip-1–EZH2 Switch Binding to Gata-4 Is Linked to the Genesis of Rhabdomyosarcoma through miR-29a

Researchers presented that GATA-4 recruited polycomb group proteins such as EZH2 to negatively regulate miR-29a in undifferentiated C2C12 myoblast cells, whereas recruitment of GRIP-1 to GATA-4 proteins displaced EZH2, resulting in the activation of miR-29a during myogenic differentiation of C2C12 cells.