Overexpression of VEGF in Dermal Fibroblast Cells Accelerates the Angiogenesis and Wound Healing Function: In Vitro and In Vivo Studies

In vitro, a novel recombinant expression vector, pcDNA3.1(-)-VEGF, was produced and transfected into fibroblast cells. Following selecting fibroblast cells with hygromycin, recombinant cells were investigated in terms of VEGF expression.