Tegument Protein UL21 of Alpha-Herpesvirus Inhibits the Innate Immunity by Triggering CGAS Degradation through TOLLIP-Mediated Selective Autophagy

Investigators demonstrated that the tegument protein UL21 in pseudorabies virus dampened type I interferon signaling by triggering the degradation of cyclic GMP-AMP synthase (CGAS) through the macroautophagy/autophagy-lysosome pathway.