JAK2V617F Mutation Drives Vascular Resident Macrophages toward a Pathogenic Phenotype and Promotes Dissecting Aortic Aneurysm

Using single-cell RNA-seq, complementary genetically-modified mouse models, as well as pharmacological approaches, investigators found that JAK2V617F mutation was associated with a pathogenic pro-inflammatory phenotype of perivascular tissue-resident macrophages, which promoted deleterious aortic wall remodeling at early stages