Role of Reactive Oxygen Species in Regulating 27-Hydroxycholesterol-Induced Apoptosis of Hematopoietic Progenitor Cells and Myeloid Cell Lines

Scientists reported that exogenous 27-Hydroxycholesterol treatment led to a substantial reduction in the hematopoietic stem and progenitor cell population owing to significantly increased reactive oxygen species levels and apoptosis in the bone marrow.