Hippo Signaling Pathway Activation during SARS-CoV-2 Infection Contributes to Host Antiviral Response

Given the complexity of COVID-19-associated cell injury and immunopathogenesis processes, scientists investigated Hippo pathway dynamics in SARS-CoV-2 infection by utilizing COVID-19 lung samples and human cell models based on pluripotent stem cell-derived cardiomyocytes and human primary lung air–liquid interface cultures.