TRIM35-Mediated Degradation of Nuclear PKM2 Destabilizes GATA4/6 and Induces P53 in Cardiomyocytes to Promote Heart Failure

Researchers studied the role of pyruvate kinase M2 (PKM2), a glycolytic enzyme, in regulating the transcription factors GATA4/6 and P53. Mice lacking PKM2 in cardiomyocytes had decreased GATA4/6 but increased P53 and developed dilated cardiomyopathy.