Targeting the MITF/APAF-1 Axis As Salvage Therapy for MAPK Inhibitors in Resistant Melanoma

Analyzing the transcriptome of MAPK inhibitor sensitive- and resistant-melanoma, scientists discovered that APAF-1 was negatively regulated by MITF in resistant tumors, identifying the MITF/APAF-1 axis as a molecular driver of MAPK inhibitor resistance.