Single-Cell Multiomics Identifies Clinically Relevant Mesenchymal Stem-Like Cells and Key Regulators for MPNST Malignancy

Investigators uncovered a nestin-negative mesenchymal neural crest-like subpopulation as a previously unknown malignant stem-like state common to murine and human malignant peripheral nerve sheath tumor (MPNST), which correlated with clinical severity.