Integrative 3D Genome and Epigenomic Analysis Identifies TP53RK and SYBU As Critical Regulators of Stemness and Anti-Tumor Immunity in HCC

Researchers delineated the 3D chromatin landscapes of well- and poorly differentiated hepatocellular carcinoma cells and uncovered stemness-associated rewiring of A/B compartmentalization, topologically associating domain boundaries, and enhancer-promoter loops.