HNRNPU Promotes the Progression of Triple-Negative Breast Cancer via RNA Transcription and Alternative Splicing Mechanisms
Investigators tested the pro-oncogenic role of heterogeneous nuclear ribonucleoprotein U (HNRNPU), which could induce the proliferation and migration of TNBC cells via its association with DEAD box helicase 5 protein.
[Molecular Psychiatry] 1275 immune-related genes were curated and their expression changes investigated in 2467 postmortem brains of controls and patients with six major brain disorders, including schizophrenia, bipolar disorder, autism spectrum disorder, major depressive disorder, Alzheimer’s disease, and Parkinson’s disease.
[Signal Transduction and Targeted Therapy] Investigators systemically analyzed lung pathogenesis in SARS-CoV-2- and its delta variant-infected humanized CD147 transgenic mice. Histopathology and Transmission Electron Microscopy revealed inflammation, fibroblast expansion and pronounced fibrotic remodeling in SARS-CoV-2-infected lungs.