Newsletters

[International Journal of Oral Science] Scientists revealed that loss of Gli3 alone in dental mesenchymal root progenitor cells caused shortened roots and that concurrent loss of Gli2 and Gli3 exacerbated root malformations, concomitant with profound impairments in cell proliferation and multilineage differentiation.

[Advanced Healthcare Materials] Researchers transfected bone MSCs with RUNX2 plasmid nanoparticles and encapsulated them into gelatin methacryloyl hydrogel microcarriers for bone regeneration.

[Stem Cell Research & Therapy] Investigators constructed endothelial progenitor cells/peripheral blood derived-MSCs sheets and evaluated their repair value and potential molecular mechanisms in bone regeneration.

[Biology Direct] Scientists integrated human umbilical cord MSCs into single-source liver organoids and assessed their effects on organoid formation and function.

[Biomacromolecules] Researchers developed poly(ethylene glycol)-derived hydrogels cross-linked with QAT-functionalized macromers. The cytocompatibility of the cross-linking was demonstrated by gelation in the presence of MESCNs and sustained cell viability.

[ACS Biomaterials Science & Engineering] Investigators elucidate the molecular mechanism by which the natural compound apigenin regulates osteoporosis-bone marrow MSCs, and its pharmacokinetic limitations are addressed with a smart delivery system, collectively offering a new strategy for the precise treatment of osteoporosis.

[Scientific Reports] Scientists identified Avenanthramide C and chondroitin sulphate as synergistic enhancers of chondrogenic differentiation in adipose-derived mesenchymal stem cells, as evidenced by the expression of articular cartilage–specific markers LRP1 and AGGRECAN, supporting their relevance for regenerative applications.

[Nature Communications] Using an endovascular injury mouse model, researchers demonstrated that perivascular MSCs enhance arterial immune response by facilitating recruitment of ST2-expressing reparative macrophages in male mice.

[European Journal of Pharmacology] Scientists evaluated the therapeutic efficacy of injectable platelet-rich fibrin, MSCs-derived exosomes, and their combination in a rat model of ethanol-induced endometrial injury.

[Stem Cell Research & Therapy] The authors summarize the current research progress on pretreated MSCs and their secretome in the treatment of kidney diseases and discuss how various pretreatment approaches can enhance their therapeutic efficacy and clinical application in renal disorders, thereby providing insights for the future optimization and therapeutic use of MSCs.

[Scinus Group] Scinus Group, a Utrecht-based startup that develops and distributes bioreactor technology for stem cell cultivation, has closed a €3 million strategic investment round to accelerate the global rollout of the Osilaris^™ cell expansion platform.

[Journal of Nanobiotechnology] Investigators systematically synthesizes contemporary advances in extracellular vesicles hydrogel systems for chronic wound therapy.