Targeting the FOXP3-T-Bet Interaction to Restore Treg Stability in IFN-γ-Driven Autoimmunity

Investigators demonstrated that predominant Th1 inflammation manifests in both FOXP3V408M IPEX patients and FOXP3V408M knock-in mice and reveal that the mutation intrinsically impairs Treg-mediated control of Th1 inflammation.