Sphingosine-1-Phosphate Controls Endothelial Sphingolipid Homeostasis via ORMDL
The researchers identified sphingosine-1-phosphate (S1P) as key sphingolipid sensed by cells via S1PRs to maintain homeostasis. The increase in S1P-S1PR signaling stabilized ORMDLs, restraining SPT activity.
[Nature Communications] Using computational tools, organoids, and spatial tools, the authors showed that LY6D+ basosquamous cells represented a persister population lying on a central node along the skin lineage-associated spectrum of epithelial states.
[Nature Communications] Scientists identified a cohort of early-stage colorectal tumors, with aggressive features and a propensity to disseminate early, that were characterized by high epithelial cell-intrinsic TGFβ signaling.