Sphingosine-1-Phosphate Controls Endothelial Sphingolipid Homeostasis via ORMDL

The researchers identified sphingosine-1-phosphate (S1P) as key sphingolipid sensed by cells via S1PRs to maintain homeostasis. The increase in S1P-S1PR signaling stabilized ORMDLs, restraining SPT activity.