Differential Integrated Stress Response and Asparagine Production Drive Symbiosis and Therapy Resistance of Pancreatic Adenocarcinoma Cells
Using metabolomic profiling and functional interrogation of metabolic dependencies, scientists identified two distinct metabolic subclasses among neoplastic populations within individual human and mouse tumors.
[Prostate Cancer Foundation] The Prostate Cancer Foundation announced four inaugural Class of 2022 TACTICAL Award recipients. This $30 million program will support cross-disciplinary pioneering research toward the goal of developing 21st Century therapies for the most life-threatening form of prostate cancer.
[Nature Communications] Researchers reported high levels of androgen receptor chromatin binding heterogeneity in human primary prostate tumors, that overlapped with heterogeneity observed in healthy prostate epithelium.