Nanoparticle-Mediated PRDX2 Inhibition for Specific Targeting of CHK2-Null Colorectal Cancer

Investigators targeted the synthetic lethal interaction between PRDX2 and CHK2 in colorectal cancer cells using N-Carbamoyl alanine-loaded chitosan nanoparticles to selectively inhibit the CHK2-null HCT116 cells.