ARID1A Loss Induces Polymorphonuclear Myeloid-Derived Suppressor Cell Chemotaxis and Promotes Prostate Cancer Progression

Researchers showed that AT-rich interactive domain-containing proteins 1 A (ARID1A), a subunit of the SWI/SNF chromatin remodeling complex, functioned downstream of inflammation-induced IKKβ activation to shape the immunosuppressive tumor microenvironment.