miR-506-3p Relieves Neuropathic Pain Following Brachial Plexus Avulsion via Mitigating Microglial Activation through Targeting the CCL2-CCR2 Axis

To investigate the function of miR-506-3p in brachial plexus avulsion-induced neuropathic pain, a total brachial plexus root avulsion model was produced in adult rats as well as IL-1β-treated motoneuron-like NSC-34 cells and the lipopolysaccharide-treated microglia cell line BV2 for in vivo and in vitro experiments, respectively.