Nuclear Localization of Mitochondrial TCA Cycle Enzymes Modulates Pluripotency via Histone Acetylation

The authors showed that tricarboxylic acid (TCA) cycle enzymes including Pdha1, Pcb, Aco2, Cs, Idh3a, Ogdh, Sdha, and Mdh2 were translocated to the nucleus during somatic cell reprogramming, primed-to-naive transition and totipotency acquisition.