A Randomized Controlled Trial Showing Safety and Efficacy of a Whole Sporozoite Vaccine against Endemic Malaria

The safety, immunogenicity, and vaccine efficacy of a three-dose regimen were assessed in adults in Balonghin, Burkina Faso in a two-component study: an open-label dose escalation trial with 32 participants, followed by a double-blind, randomized, placebo-controlled trial with 80 participants.