Cross-Talk between TSC2 and the Extracellular Matrix Controls Pulmonary Vascular Proliferation and Pulmonary Hypertension

ECM produced by tuberous sclerosis complex 2 (TSC2)-deficient pulmonary artery vascular smooth muscle cells (PAVSMCs) stimulated the proliferation of nondiseased PA adventitial fibroblasts and PAVSMCs through fibronectin and its receptor.