Arsenic Trioxide Promotes ERK1/2-Mediated Phosphorylation and Degradation of BIMEL to Attenuate Apoptosis in BEAS-2B Cells

Scientists found that arsenic trioxide decreased BCL-2-interacting mediator of cell death protein (BIMEL) levels in human bronchial epithelial cell line and increased BIMEL levels in human lung carcinoma cell line A549 and mouse Sertoli cell line TM4.