RNA Degradation Eliminates Developmental Transcripts during Murine Embryonic Stem Cell Differentiation via CAPRIN1-XRN2

To identify non-nuclear regulators of ESCs, scientists screened an endogenously labeled fluorescent fusion-protein library in mESCs. Cell-cycle-associated protein 1 (CAPRIN1) knockout had little effect in ESCs, but it significantly altered differentiation and gene expression programs.