Chronic Gper Activation Prompted the Proliferation of Ileal Stem Cell in Ovariectomized Mice Depending on Paneth Cell Derived Wnt3

Investigators tested the effect of chronic G protein-coupled estrogen receptor (GPER) activation on intestinal stem cells of ovariectomized (OVX) mice by injection of the selective GPER agonist G-1 for 28 days, or G-1 stimulation of organoids derived from crypts of OVX mice.