Pals1 Functions in Redundancy with SMAP1 to Inhibit Arf6 in Order to Prevent Rac1-Dependent Colorectal Cancer Cell Migration and Invasion

Scientists identified a redundancy between SMAP1 and Pals1 in the regulation of activation of Arf6/Rac1, thereby controlling cell migration, invasion, and metastasis of colorectal cancer cells.