Synergistic Combination of Targeted Nano-Nuclear-Reactors and Anti-PD-L1 Nanobodies Evokes Persistent T Cell Immune Activation for Cancer Immunotherapy

Scientists reported that Fe-doped and doxorubicin loaded HA@Cu2−XS-PEG nanomaterials were rationally designed as targeted Fe-PHCN@DOX nano-nuclear-reactors, which evoked persistent T cell immune response together with anti-PD-L1 nanobodies.