Manganese-Coordinated mRNA Vaccines with Enhanced mRNA Expression and Immunogenicity Induce Robust Immune Responses against SARS-CoV-2 Variants

Investigators constructed a novel mRNA delivery system (IC8/Mn lipid nanoparticles) with high immunogenicity, via introducing a stimulator of interferon genes (STING) agonist manganese based on a newly synthesized ionizable lipid (IC8).