Antigen-Specific TCR-T Cells from Rag2 Gene-Deleted Pluripotent Stem Cells Impede Solid Tumor Growth in a Mouse Model

To improve the homogeneity, antigen-specificity, and reduce possible autoreactivity, investigators developed a technique to generate antigen-specific T cells from Rag2 gene-deleted PSCs and further measured their anti-tumor efficacy.