PD-1 Signaling Defines and Protects Leukemic Stem Cells from T Cell Receptor-Induced Cell Death in T Cell Acute Lymphoblastic Leukemia

Using lineage tracing, limiting dilution assays, and in vivo live imaging approaches, scientists identified a rare inhibitory receptor programmed cell death 1 (PD-1)-expressing cells that resided at the apex of leukemia hierarchy for initiation and relapse in T cell acute lymphoblastic laukemia.