NewslettersOrganoid NewsPancreatic Cell NewsTargeting Src Reactivates Pyroptosis to Reverse Chemoresistance in Lung and Pancreatic Cancer ModelsBy lbeveridge - January 12, 20230252Researchers demonstrated that β5-integrin repressesed chemotherapy-induced canonical pyroptosis to confer cancer chemoresistance through ASAH2-driven sphingolipid metabolic reprogramming.[Science Translational Medicine]Abstract