E3-Ligase TRIM31 Regulates Hematopoietic Stem Cell Homeostasis and MLL-AF9 Leukemia

Scientists found that the E3 ligase-TRIM31 regulated HSC homeostasis and leukemia through the accumulation of CDK8. TRIM31 deficiency promoted hematopoietic stem and progenitor cell proliferation and long-term HSC exhaustion.