Aberrant Promoter Hypermethylation of miR-335 and miR-145 Is Involved in Breast Cancer PD-L1 Overexpression

Investigators studied the role of miR-335 and -145 on programmed cell death 1 receptor-ligand (PD-L1) suppression in breast cancer (BC). The expression of miR-355 and miR-145 was significantly downregulated in BC tissues and cell lines compared to their controls, and their downregulation was negatively correlated with PD‐L1 overexpression.