TRIM15 Forms a Regulatory Loop with the AKT/FOXO1 Axis and LASP1 to Modulate the Sensitivity of HCC Cells to TKIs
Scientists demonstrated that TRIM15 was abnormally upregulated in liver cancer cells after treated with tyrosine kinase inhibitors and that this upregulation of TRIM15 contributed to TKI resistance in liver cancer cells.
[Scientific Reports] Scientists identified miRNA that were up-regulated in satellite cell-derived myoblasts treated with stromal derived factor-1 (SDF-1) and/or down-regulated in cells in which the expression of CXCR4 or CXCR7, that is, SDF-1 receptors, was silenced.
[Cell Death & Disease] Investigators revealed that Krüppel-like factor 4 (KLF4) played a critical role in skeletal muscle development and regeneration. Specific knockout of KLF4 in skeletal muscle impaired muscle formation further affecting physical activity and also defected skeletal muscle regeneration.
[Nature Structural & Molecular Biology] Scientists showed that the ability of SS18-SSX to occupy H2AK119ub1-rich regions was an intrinsic property of its SSX C terminus, which could be exploited by fusion to transcriptional regulators beyond SS18.