TRIM15 Forms a Regulatory Loop with the AKT/FOXO1 Axis and LASP1 to Modulate the Sensitivity of HCC Cells to TKIs
Scientists demonstrated that TRIM15 was abnormally upregulated in liver cancer cells after treated with tyrosine kinase inhibitors and that this upregulation of TRIM15 contributed to TKI resistance in liver cancer cells.
[British Journal of Cancer] The immunoproteasome subunit LMP7 was silenced by using gene knockout or inhibited by the epoxyketone inhibitor ONX 0914 in a mouse castration-resistant prostate cancer (CRPC) tumor graft model and in interferon-γ-pretreated human CRPC cell lines in vitro.
[British Journal of Cancer] 582 mCRPC patients undergoing first-line abiraterone therapy from four institutions were sorted by three phases: discovery, training, and validation.
[International Journal of Radiation Oncology*Biology*Physics] Researchers performed an international multi-institutional retrospective study of 277 men with metachronous oligometastatic castration-sensitive prostate cancer who underwent targeted DNA sequencing of their primary/metastatic tumor.