Extracellular Vesicle-Mediated miR-126-3p Transfer Contributes to Inter-cellular Communication in the Liver Tumor Microenvironment

Using both transwell and spheroid co‑cultures of liver cancer (LC) cells and hepatic stellate cells (HSCs), miR‑126‑3p within extracellular vesicles (EV) was established as a mediator of HSC to LC cell communication that influenced tumor cell migration and invasion, as well as the growth of multicellular LC/HSC spheroids.