Artepillin C Overcomes Apalutamide Resistance through Blocking Androgen Signaling in Prostate Cancer Cells

To search for compounds which overcame the resistance to apalutamide, scientists established apalutamide-resistant prostate cancer 22Rv1 cells (22Rv1/APA). The 22Rv1/APA cells showed higher androgen receptor expression and androgen sensitivity than parental 22Rv1 cells.