Transplanted Human iPSC-Derived Vascular Endothelial Cells Promote Functional Recovery by Recruitment of Regulatory T Cells to Ischemic White Matter in the Brain
The authors investigated contribution of the immune system, especially Tregs, to the mechanism whereby human induced pluripotent stem cell transplantation ameliorated white matter infarct.
[Science Advances] Scientists used single-nucleus RNA sequencing to characterize a mouse model that mimicked human nonalcoholic steatohepatitis (NASH)–driven HCC, the MUP-uPA mouse fed a high-fat diet.
[JHEP Reports] Mouse liver perfusion was used to identify the effects of interstitial flow on hepatocyte proliferation ex vivo. Isolated hepatocytes in vitro were further exposed to varied shear stresses directly.
[JHEP Reports] Cholangiocarcinoma (CCA) tumor microenvironment was recapitulated on a microfluidic three-channel chip using primary CCA cells, cancer-associated fibroblasts, endothelial cells, and T cells isolated from CCA specimens.