Pancreatic Stellate Cell-Induced Gemcitabine Resistance in Pancreatic Cancer Is Associated with LDHA- and MCT4-Mediated Enhanced Glycolysis

Human pancreatic cancer cell lines were exposed to three different pancreatic stellate cells-conditioned media, following either pre-treatment with glycolysis inhibitor NV-5440 or transfection for transient silencing of key glycolytic regulators .