Mechanosensitive miR-99b Mediates the Regulatory Effect of Matrix Stiffness on Bone Marrow Mesenchymal Stem Cell Fate Both In Vitro and In Vivo

Researchers found that the expression of miR-99b increased with increasing hydrogel stiffness and that miR-99b regulated the proliferation and differentiation of BMSCs seeded on the surface of substrates with different stiffnesses.