Cullin-5 Deficiency Orchestrates the Tumor Microenvironment to Promote Mammary Tumor Development through CREB1-CCL2 Signaling

Scientists used both the sleeping beauty transposon mutagenesis system and CRISPR-Cas9–mediated genome-wide screening in mice to identify potential genetic alterations that acted synergistically with breast cancer–associated gene 1 deficiency to promote tumorignesis.