Hepatic TNFRSF12A Promotes Bile Acid-Induced Hepatocyte Pyroptosis through NFκB/Caspase-1/GSDMD Signaling in Cholestasis

Human hepatoma PLC/PRF/5-ASBT and THP1 cell lines or primary mouse hepatocytes were used for mechanistic studies. Hepatic TNFRSF12A expression was markedly increased in obstructive cholestasis or primary biliary cholangitis patients.