Tuning the Corona-Core Ratio of Polyplex Micelles for Selective Oligonucleotide Delivery to Hepatocytes or Hepatic Immune Cells
Applying Raman-spectroscopy and dynamic in silico modeling on the polyplex micelles, researchers determined the corona-core ratio (CCR) and visualized the possible micellar structure with varying CCR.
[Signal Transduction and Targeted Therapy] Investigators showed that the oncogenic BCR-ABL1 of chronic myelogenous leukemia and the cellular ABL1 tyrosine kinases phosphorylated and inactivated Smad4 to block antiproliferative TGF-β signaling.
[Science of The Total Environment] RNA interference was performed to understand the function of astakine in hematopoiesis and apoptosis in Litopenaeus vannamei under ammonia-N exposure.
[Cell Reports] The authors integrated extensive longitudinal functional assessments of HSC-specific lineage tracing with single-cell transcriptome and epitope profiling.