Noncoding RNA circBtnl1 Suppresses Self-Renewal of Intestinal Stem Cells via Disruption of Atf4 mRNA Stability

Researchers identified a circular RNA, circBtnl1, that was highly expressed in intestinal stem cells. Loss of circBtnl1 in mice enhanced intestinal stem cell self-renewal capacity and epithelial regeneration, without changes in mRNA and protein levels of its parental gene Btnl1.